Motilium – Gastrointestinal Problems Are Not an Issue Anymore

Motilium (domperidone) is an antiemetic medication that contains a dopaminergic blocking agent and is commonly used for the management of various gastrointestinal motility conditions caused by chronic or mild forms of gastritis. This medication is used in case a patient suffers from gastrointestinal symptoms that are related to the intake of dopamine agonist medications against Parkinson disease. It belongs to the group of butyrophenones, while its effects are achieved through the stimulation of peristalsis and blocking of dopamine receptors.

Motilium helps decrease the time of transition to the small bowel by lowering the pressure in one’s stomach and improving peristalsis. Antiemetic functions of Motilium are associated with the blocking of dopamine receptors at the brain and gastric levels. The therapeutic effects of this medication include the relief of such symptoms as nausea and vomiting.

How to Use Motilium

Motilium needs to be administered in the lowest dose that is suggested to be most effective. It should also be used for the shortest period of time if it is possible. In case the symptoms of nausea and vomiting alleviate, the treatment with Motilium needs to be stopped. It is recommended to follow the instructions contained in the leaflet to the drug. As a rule, the following recommendations need to be considered when taking Motilium:

  • This medication is intended for oral use and needs to be taken before meals. If taken after food, the absorption of the medication may be postponed;
  • Patients need to take each dose at the planned time. In case some dose is skipped, it should be omitted and the regular dosing regimen needs to be continued. The dose should not be increased twice in order to compensate the missed dosage;
  • The duration of treatment with Motilium may vary, but as a rule, it should not exceed a week;
  • As for the recommended dosage, adults and young people aged more than 12 years old need to take 10 mg of the drug three times a day, while the ultimate dose for adult patients should not exceed 30 mg a day. Infants and children aged below 12 should not take this drug, especially if their weight is less than 35 kg;
  • It is recommended to take this medication 30 minutes before eating or right before going to bed. Even if you take higher doses of the drug, your condition is unlikely to get better, but the side effects may be severe;
  • Motility problems require smaller doses than such symptoms as nausea and vomiting. In case of the latter, the recommended dose would be 20 mg three or four times a day taken by mouth. Motility disorders require taking 10 mg three or four times during the day and before going to bed.

Potential Side Effects

As a rule, Motilium is well-tolerated, and the majority of adverse reactions go away throughout the length of treatment. However, there are certain adverse reactions that can be resolved by lowering the dose or even discontinuation of the treatment. The following adverse reactions may occur in patients who take Motilium:

  • Increased thirst;
  • Headache;
  • Conjunctivitis (pain, redness, irritation or swelling of eyes);
  • Menstrual changes;
  • Galactorrhea;
  • Feeling nervous, irritated or disoriented;
  • Constipation or diarrhea;
  • Increase of breast volume in male patients;
  • Chest pain;
  • Skin rash, hives and itching;
  • Swelling of body parts;
  • Signs of lethargy (feeling drowsy, sluggish or tired without a reason).

Due to the effects produced by Motilium on dopamine activity, the intake of this medication may lead to the development of extrapyramidal side effects that usually alleviate as soon as the treatment process comes to an end.


If you are suspecting overdose, seek immediate medical attention to avoid negative health outcomes. The following signs and symptoms may take place in case a patient has taken too much of this drug and suffers from overdose:

  • Feeling dizzy as if you are about to faint;
  • Increased or decreased heart rate;
  • Feeling disoriented and confused;
  • Extrapyramidal adverse reactions (loss of muscle regulation, imbalance and speaking problems);
  • Signs of low blood pressure (feeling lightheaded when getting up bed, feeling dizzy and about to lose consciousness).

These symptoms generally disappear within a period of up to 24 hours. There is no special antidote against overdose with Motilium. However, anticholinergic, anti-parkinsonian and antihistamine drugs may be effective in managing the extrapyramidal reactions to this drug associated with its increased toxic effects. Activated charcoal may also be helpful in eliminating the excess amounts of the drug from the blood system of a patient. It is advisable to contact the local poison control agency in case the symptoms of overdose are especially severe. This will allow preventing irreversible health consequences.

Warnings: Before Taking This Medication

Let your doctor know about any associated conditions contained in your medical record, especially when it comes to such health issues as allergies and breast cancer. Avoid taking alcoholic beverages for the duration of the treatment with Motilium. This medication can be used during pregnancy only if potential benefits outweigh possible risks, which should be discussed with your physician. Motilium may pass into breast milk. As such, it is not recommended to take this drug when nursing a baby. Consult a physician before administering this drug when breastfeeding.

Possible Drug Interactions

Due to the fact that this medication increases the movement inside the digestive system, it may influence the rate of absorption and effects of other medications. As such, it is important to let your doctor know about any non-prescription or prescription drugs you are currently taking. This is especially vital if you are taking MAOIs. Do not start taking this medication without a preliminary consultation with your doctor or pharmacist. Do not stop the treatment process before you get an approval from your physician.